Get access

pH-Responsive Nutraceutical–Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability

Authors

  • Rémy Guillet-Nicolas,

    1. Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, G1V 0A6, Quebec, QC (Canada)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Amirali Popat,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    2. School of Pharmacy, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Jean-Luc Bridot,

    1. Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, G1V 0A6, Quebec, QC (Canada)
    Search for more papers by this author
  • Prof. Gregory Monteith,

    1. School of Pharmacy, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
  • Prof. Shi Zhang Qiao,

    Corresponding author
    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    2. School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005 (Australia)
    • Shi Zhang Qiao, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)===

      Freddy Kleitz, Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, G1V 0A6, Quebec, QC (Canada)===

    Search for more papers by this author
  • Prof. Freddy Kleitz

    Corresponding author
    1. Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, G1V 0A6, Quebec, QC (Canada)
    • Shi Zhang Qiao, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)===

      Freddy Kleitz, Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, G1V 0A6, Quebec, QC (Canada)===

    Search for more papers by this author

  • The authors acknowledge financial support from the Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT), the Australian Research Council (ARC), and the AER program of Université Laval.

Abstract

original image

An innovative platform for targeted oral drug delivery is proposed based on the functionalization of drug/dye-loaded mesoporous silica nanoparticles (MSNs) with a biodegradable nutraceutical (β-lactoglobulin). The attachment of the nutraceutical not only protects the drug/dye from leaching in acidic environment, but also effectively allows their release in desired basic sites (pH 7.4).

Ancillary