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Magnetogenesis under Physiological Conditions with Probes that Report on (Bio-)Chemical Stimuli


  • We thank Erwann Jeanneau for X-ray structural analyses, Olivier Beuf for MR imaging acquisitions, and Laurence Canaple and Jacques Samarut for stimulating discussions.


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Switched on: A molecular concept allows the generation of magnetism in an aqueous sample under the influence of a freshly added (bio-)chemical analyte. The analyte (a chemical reagent or enzyme) triggers the conversion of the probe, a diamagnetic chelate compound, into a paramagnetic compound (see scheme). The two probes prepared are easily accessible iron(II) chelates, and are operative at physiological conditions and/or in serum.