We thank the EPSRC (EP/E061575/1) for postdoctoral funding. K.G.M. thanks the EPSRC-funded Bristol Chemical Synthesis Doctoral Training Centre (EP/G036764/1), AstraZeneca for a PhD studentship. We also thank P. Dinham and P. Chappell for reactor construction.
Complexity from Simplicity: Tricyclic Aziridines from the Rearrangement of Pyrroles by Batch and Flow Photochemistry†
Article first published online: 10 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 5, pages 1499–1502, January 28, 2013
How to Cite
Maskill, K. G., Knowles, J. P., Elliott, L. D., Alder, R. W. and Booker-Milburn, K. I. (2013), Complexity from Simplicity: Tricyclic Aziridines from the Rearrangement of Pyrroles by Batch and Flow Photochemistry . Angew. Chem. Int. Ed., 52: 1499–1502. doi: 10.1002/anie.201208892
- Issue published online: 23 JAN 2013
- Article first published online: 10 JAN 2013
- Manuscript Received: 6 NOV 2012
- EPSRC. Grant Numbers: EP/E061575/1, EP/G036764/1
- flow chemistry;
Molecular acrobatics: Irradiation of N-butenyl-substituted pyrroles that bear an electron-withdrawing group leads to complex tricyclic aziridines through an unprecedented photocycloaddition–rearrangement sequence. Gram quantities of these complex products could be produced by using a bespoke flow reactor (see picture, FEP=fluorinated ethylene propylene).