Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones


  • This work was supported by the 973 Program (2012CB725302), the National Natural Science Foundation of China (21025206 and 21272180), and the China Postdoctoral Science Foundation funded project (2012M521458). We are also grateful for the support from the Program for Changjiang Scholars and Innovative Research Team in University (IRT1030).


original image

Let's get radical: The first copper-catalyzed oxidative coupling of alkenes and aldehydes was developed. Various aldehydes were utilized as substrates to construct α,β-unsaturated ketones. A preliminary mechanistic study indicated that this reaction is likely to proceed through a single-electron transfer.