Redox-Controlled Selectivity of C[BOND]H Activation in the Oxidative Cross-Coupling of Arenes


  • We gratefully acknowledge the Engineering and Physical Sciences Research Council for generous funding, the European Research Council for a Starting Research Grant (to I.L.) and the EPSRC National Mass Spectrometry Service (Swansea).


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Gold brings us together: Taking advantage of the orthogonal reactivities of AuI and AuIII towards C[BOND]H activation of electron-poor and electron-rich arenes, respectively, a novel approach for the synthesis of biaryls through double C[BOND]H activation is proposed. Stoichiometric studies demonstrate that these oxidative couplings occur with high selectivity at low temperature.