Synthesis of Single-Chain Sugar Arrays

Authors

  • Nathalie Baradel,

    1. Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
    Search for more papers by this author
  • Dr. Sébastien Fort,

    1. Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
    Search for more papers by this author
  • Dr. Sami Halila,

    1. Oligosaccharides Chemistry and Biotechnology, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP 53, 38041 Grenoble Cedex 9 (France)
    Search for more papers by this author
  • Dr. Nezha Badi,

    1. Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
    Search for more papers by this author
  • Dr. Jean-François Lutz

    Corresponding author
    1. Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)
    • Precision Macromolecular Chemistry, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2 (France)===

    Search for more papers by this author

  • The research leading to these results was partially funded by the European Research Council under the Seventh Framework Program of the European Union (FP7/2007-2013) and the ERC grant agreement No. 258593. The CNRS, the University of Strasbourg, and the icFRC are also acknowledged for financial support. We thank M. Legros, O. Gavat, and C. Foussat for the SEC measurements. P. Chaud and S. Pradeau are also acknowledged for their help in the preparation of azido sugars.

Abstract

original image

Polymers that toe the line: Well-defined linear polystyrene chains containing precisely positioned hexose moieties (mannose, galactose, and N-acetylglucosamine) were synthesized by a sequence-controlled polymerization approach followed by a series of site-selective modification steps. Such multifunctional single-chain hexose arrays associate specifically with complementary lectins (see picture).

Ancillary