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Keywords:

  • asymmetric catalysis;
  • Mannich reaction;
  • silyl ketene imine;
  • multicomponent reactions;
  • β-amino nitrile
Thumbnail image of graphical abstract

A range of β-amino nitriles containing contiguous tertiary and quaternary stereogenic carbon centers were synthesized by using the title reaction. The reaction was catalyzed by a chiral N,N′-dioxide scandium(III) complex under mild reaction conditions. Based on experimental investigations, a possible transition state has been proposed to explain the origin of asymmetric inductivity.