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Cross-Metathesis/Iridium(I)-catalyzed Allylic Etherification Strategy: (Iterative) Catalytic Asymmetric Synthesis of syn- and anti-1,2-Diols

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  • Research reported in this publication was supported by the US National Science Foundation (CHE 0911134).

Abstract

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Protection optional: The title reaction strategy is used to prepare 1,2-diols with complete control of their absolute and relative stereochemistry. The method tolerates free and Me-/Bn-/TBS-protected alcohol functionalities, and its diastereoselectivity is controlled by the stereochemistry of the ligands/catalysts used. Protected 1,2,3,4-tetraols are synthesized by iterative applications of the strategy.

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