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Keywords:

  • multiplexed assay;
  • protein-protein interactions;
  • receptors;
  • signal transduction;
  • surface-immobilization
Thumbnail image of graphical abstract

Taking the bait: Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.