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Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules

Authors

  • Prof. Dr. Yuko Yoshikawa,

    Corresponding author
    1. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • Dr. Naoki Umezawa,

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • Yuki Imamura,

    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
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  • Prof. Dr. Toshio Kanbe,

    1. Laboratory of Medical Mycology, School of Medicine, Nagoya University, Nagoya 464-0064 (Japan)
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  • Dr. Nobuki Kato,

    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
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  • Prof. Dr. Kenichi Yoshikawa,

    1. Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe 610-0394 (Japan)
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  • Prof. Dr. Tadayuki Imanaka,

    1. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)
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  • Prof. Dr. Tsunehiko Higuchi

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • This research was supported in part by Grants-in-Aid for Scientific Research from the Japan Science and Technology Agency CREST program, and from the Japan Society for the Promotion of Science (20249006, 22510123, 23240044, 23659058, and 24590142).

Abstract

original image

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

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