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Keywords:

  • biosensors;
  • DNA aptamers;
  • nanopores;
  • self-assembly;
  • smart materials
Thumbnail image of graphical abstract

Pore me another one: Sub-nanomolar sequence-specific DNA detection and sub-micromolar small-molecule (ATP) detection was shown by way of self-assembly and disassembly of DNA superstructures within solid-state nanopores (see scheme). These DNA structures provide a built-in amplification mechanism to increase the signal strength and sensitivity. This sensor was also shown to work within complex mixtures, such as mammalian serum.