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Keywords:

  • carbenes;
  • difluoromethylation;
  • fluorine;
  • one-pot reactions;
  • phenols
Thumbnail image of graphical abstract

The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.