The authors thank the NIH-NIGMS (R29-55382) for support of this work.
Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate†
Article first published online: 10 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 7, pages 2092–2095, February 11, 2013
How to Cite
Fier, P. S. and Hartwig, J. F. (2013), Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate . Angew. Chem. Int. Ed., 52: 2092–2095. doi: 10.1002/anie.201209250
- Issue published online: 6 FEB 2013
- Article first published online: 10 JAN 2013
- Manuscript Received: 19 NOV 2012
- NIH-NIGMS. Grant Number: R29-55382
- one-pot reactions;
The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.