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Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate


  • The authors thank the NIH-NIGMS (R29-55382) for support of this work.


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The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.