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Stille Coupling Involving Bulky Groups Feasible with Gold Cocatalyst


  • We thank the Spanish Ministerio de Ciencia e Innovación (CTQ2010-18901/BQU) and the Junta de Castilla y León (VA281A11-2 and VA373A11-2) for financial support.


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Gold shuttle: Bulky groups, which will not (or only very sluggishly) undergo Stille coupling with stannanes and inexpensive ligands, can be efficiently coupled using bimetallic catalysis. A gold cocatalyst serves as an efficient shuttle to convey the bulky group from tin to palladium by reducing the steric crowding in the transition-states (see scheme).