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A R2p/R1p Ratiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging

Authors

  • Dr. Valeria Catanzaro,

    1. Istituto di Ricerca Diagnostica e Nucleare SDN, Via Gianturco 113, 80143 Napoli (Italy)
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  • Dr. Concetta V. Gringeri,

    1. Department of Science and Technological Innovation, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria (Italy)
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  • Dr. Valeria Menchise,

    1. Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, 10125 Torino (Italy)
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  • Dr. Sergio Padovan,

    1. Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, 10125 Torino (Italy)
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  • Dr. Cinzia Boffa,

    1. Department of Chemisty & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino (Italy)
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  • Dr. Walter Dastrù,

    1. Department of Chemisty & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino (Italy)
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  • Dr. Linda Chaabane,

    1. Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan (Italy)
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  • Dr. Giuseppe Digilio,

    Corresponding author
    1. Department of Science and Technological Innovation, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria (Italy)
    • Department of Science and Technological Innovation, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria (Italy)
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  • Prof. Silvio Aime

    Corresponding author
    1. Department of Chemisty & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino (Italy)
    • Department of Chemisty & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino (Italy)
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  • This research was supported by funding from MEDITRANS (NMP4-CT-2006-026668), Regione Piemonte (Converging Technologies BIO-THER project; POR-FESR 2007-2013 “Piattaforme Innovative”, PIIMDMT project) and MIUR PRIN 2010 no. 2010B5B2NL. C. Chirizzi and M. Capozza are acknowledged for technical assistance.

Abstract

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Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

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