Generous financial support from the Deutsche Forschungsgemeinschaft (SFB 858) and the Fonds der Chemischen Industrie (M.S.) is gratefully acknowledged. The research of F.G. is supported by the Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen and Halbach Foundation. We thank Nathalie E. Wurz for helpful discussions and Mirco Fleige and Karin Gottschalk for skillful technical support. NHC=N-heterocyclic carbene.
NHC-Catalyzed Hydroacylation of Styrenes†
Article first published online: 25 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 9, pages 2585–2589, February 25, 2013
How to Cite
Schedler, M., Wang, D.-S. and Glorius, F. (2013), NHC-Catalyzed Hydroacylation of Styrenes . Angew. Chem. Int. Ed., 52: 2585–2589. doi: 10.1002/anie.201209291
- Issue published online: 19 FEB 2013
- Article first published online: 25 JAN 2013
- Manuscript Received: 20 NOV 2012
- Deutsche Forschungsgemeinschaft. Grant Number: SFB 858
- Fonds der Chemischen Industrie
- N-heterocyclic carbenes;
- synthetic methods
New hydroacylation catalysts: Highly electron-rich N-heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron-withdrawing group, EDG=electron-donating group.