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NHC-Catalyzed Hydroacylation of Styrenes

Authors

  • Michael Schedler,

    1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • Dr. Duo-Sheng Wang,

    1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • Prof. Dr. Frank Glorius

    Corresponding author
    1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
    • Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • Generous financial support from the Deutsche Forschungsgemeinschaft (SFB 858) and the Fonds der Chemischen Industrie (M.S.) is gratefully acknowledged. The research of F.G. is supported by the Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen and Halbach Foundation. We thank Nathalie E. Wurz for helpful discussions and Mirco Fleige and Karin Gottschalk for skillful technical support. NHC=N-heterocyclic carbene.

Abstract

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New hydroacylation catalysts: Highly electron-rich N-heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron-withdrawing group, EDG=electron-donating group.

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