An Asymmetric Diels–Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles


  • We thank the National Institutes of Health (NIH GM-082935) and the National Science Foundation CAREER Program (NSF-0847108) for financial support.


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Mild Magic: A mild, enantioselective Diels–Alder reaction, catalyzed by a chiral magnesium phosphate species, has been developed for the synthesis of various chiral spirooxindoles. Molecular sieves were found to have a considerable effect when used as additives in this reaction.