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Keywords:

  • anticancer agent;
  • asymmetric synthesis;
  • drug design;
  • macrolide;
  • superstolide analogue
Thumbnail image of graphical abstract

By design: A truncated superstolide A, a simplified analogue of the potent anticancer marine macrolide superstolide A, was designed and successfully synthesized by a highly efficient and convergent approach. The biological evaluation showed that this compound maintains the potent anticancer activity of the original natural product superstolide A.