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Design, Synthesis, and Biological Evaluation of Truncated Superstolide A

Authors

  • Dr. Lei Chen,

    1. Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
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  • Kausar Begam Riaz Ahmed,

    1. Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 (USA)
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  • Prof. Dr. Peng Huang,

    1. Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 (USA)
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  • Prof. Dr. Zhendong Jin

    Corresponding author
    1. Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
    • Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
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  • This work was made possible by the generous support of the NIH (5R01CA109208).

Abstract

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By design: A truncated superstolide A, a simplified analogue of the potent anticancer marine macrolide superstolide A, was designed and successfully synthesized by a highly efficient and convergent approach. The biological evaluation showed that this compound maintains the potent anticancer activity of the original natural product superstolide A.

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