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Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters

Authors

  • Prof. Dr. Yujiro Hayashi,

    Corresponding author
    1. Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan)
    2. Present address: Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578 (Japan)
    • Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan)
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  • Shigenobu Umemiya

    1. Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan)
    2. Present address: Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578 (Japan)
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  • This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas “Advanced Molecular Transformations by Organocatalysts” from The Ministry of Education, Culture, Sports, Science and Technology (Japan). The authors thank Prof. Hayato Ishikawa at Kumamoto University, Dr. Takuya Seko, and Dr. Toru Maruyama at Ono pharmaceutical Co., Ltd. for their helpful discussions.

Abstract

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Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

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