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Keywords:

  • allylic compounds;
  • amino acid;
  • asymmetric synthesis;
  • heterocycles;
  • palladium
Thumbnail image of graphical abstract

To All(oc) involved: A palladium-catalyzed formal 5-endo-trig heteroannulation of enones generated in situ from amino acid derived β-keto nitriles has been realized (see scheme; Alloc=allyl carbamate). The reaction proceeds with allyl-group transfer from the carbamate protecting group to generate two new contiguous stereocenters, including one quaternary center, with high selectivity.