This BIOFLUORG project was funded by the European Union and through support by the Region Haute-Normadie FEDER. We also thank Dr. M. Sanselme for X-ray structure determination.
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Communication
Palladium- and Copper-Catalyzed Stereocontrolled Direct C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H Fluoroalkenylation of Heteroarenes using gem-Bromofluoroalkenes†
Article first published online: 30 JAN 2013
DOI: 10.1002/anie.201209446
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Schneider, C., Masi, D., Couve-Bonnaire, S., Pannecoucke, X. and Hoarau, C. (2013), Palladium- and Copper-Catalyzed Stereocontrolled Direct CH Fluoroalkenylation of Heteroarenes using gem-Bromofluoroalkenes . Angew. Chem. Int. Ed., 52: 3246–3249. doi: 10.1002/anie.201209446
- †
Publication History
- Issue published online: 7 MAR 2013
- Article first published online: 30 JAN 2013
- Manuscript Received: 26 NOV 2012
Funded by
- European Union
Keywords:
- bromofluoroalkenes;
- C-H activation;
- fluoroalkenylation;
- heterocycles;
- palladium
A gem of a reaction: The palladium- and copper-catalyzed base-assisted direct CH fluoroalkenylation of heterocycles 1 with gem-bromofluoroalkenes (E)-2 is reported. This method offers step-economical and stereocontrolled access to valuable trisubstituted heteroarylated monofluoroalkenes (Z)-3.