Palladium- and Copper-Catalyzed Stereocontrolled Direct C[BOND]H Fluoroalkenylation of Heteroarenes using gem-Bromofluoroalkenes


  • This BIOFLUORG project was funded by the European Union and through support by the Region Haute-Normadie FEDER. We also thank Dr. M. Sanselme for X-ray structure determination.


original image

A gem of a reaction: The palladium- and copper-catalyzed base-assisted direct C[BOND]H fluoroalkenylation of heterocycles 1 with gem-bromofluoroalkenes (E)-2 is reported. This method offers step-economical and stereocontrolled access to valuable trisubstituted heteroarylated monofluoroalkenes (Z)-3.