These authors contributed equally to this work.
Aerobic Oxidative Heck/Dehydrogenation Reactions of Cyclohexenones: Efficient Access to meta-Substituted Phenols†
Article first published online: 19 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 13, pages 3672–3675, March 25, 2013
How to Cite
Izawa, Y., Zheng, C. and Stahl, S. S. (2013), Aerobic Oxidative Heck/Dehydrogenation Reactions of Cyclohexenones: Efficient Access to meta-Substituted Phenols. Angew. Chem. Int. Ed., 52: 3672–3675. doi: 10.1002/anie.201209457
We thank Dr. Doris Pun for assistance in product purification. Financial support was provided by the NIH (R01 GM100143), Mitsubishi Chemical Corporation, and the Shanghai Institute of Organic Chemistry (postdoctoral fellowship for C.W.Z.).
- Issue published online: 20 MAR 2013
- Article first published online: 19 FEB 2013
- Manuscript Received: 27 NOV 2012
- NIH. Grant Number: R01 GM100143
- Mitsubishi Chemical Corporation
- Shanghai Institute of Organic Chemistry
- Heck reaction;
- synthetic methods
Jockeying for the (meta)position: A new dicationic palladium(II) catalyst, employing a 6,6′-dimethyl-2,2′-bipyridine ligand, promotes both the aerobic oxidative Heck coupling and dehydrogenation reactions of cyclohexenones. These reactions may be combined in a one-pot sequence to enable the straightforward synthesis of meta-substituted phenols (see scheme).