Bypassing the Limitations of Classical Chemical Purification with DNA-Programmable Nanoparticle Recrystallization

Authors

  • Matthew R. Jones,

    1. Department of Materials Science & Engineering, Northwestern University (USA)
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  • Prof. Chad A. Mirkin

    Corresponding author
    1. Department of Chemistry, Materials Science & Engineering and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
    • Department of Chemistry, Materials Science & Engineering and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
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  • C.A.M. acknowledges the following awards for support of this work: AFOSR FA9550-09-1-0294, FA9550-11-1-0275 and FA9550-12-1-0280, DoD/NSSEFF/NPS N00244-09-1-0012 and N00244-09-1-0071, NSF MRSEC DMR-1121262, and the DoE/Office of Science/Office of Basic Energy Sciences NERC DE-SC0000989. M.R.J. is grateful to the NSF for a Graduate Research Fellowship and to Northwestern University for a Ryan Fellowship. Small-angle X-ray scattering was carried out at the DuPont-Northwestern-Dow Collaborative Access Team (DND-CAT) beamline located at Sector 5 of the Advanced Photon Source (APS). DND-CAT is supported by E. I. DuPont de Nemours & Co., The Dow Chemical Company, and the State of Illinois. Use of the APS was supported by US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. The ICP-AES analysis was completed at the Northwestern University Integrated Molecular Structure Education and Research Center (IMSERC).

Abstract

original image

And then there was one: Anisotropic nanoparticle syntheses often contain impurity nanostructures. Functionalization of the products of such syntheses with DNA (see scheme (1)) allows the relative interaction strengths between particles to be tailored. The desired nanoparticle component can then be crystallized selectively (2) and separated to arrive at samples of significantly improved purity (3).

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