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Efficient Synthesis of Helical Tetrasubstituted Alkenes as Potential Molecular Switches: A Two-Component Palladium-Catalyzed Triple Domino Process

Authors

  • Prof. Dr. Lutz F. Tietze,

    Corresponding author
    1. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
    • Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)===

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  • Tim Hungerland,

    1. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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  • Christoph Eichhorst,

    1. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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  • Dr. Alexander Düfert,

    1. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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  • Christian Maaß,

    1. Institute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany)
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  • Prof. Dr. Dietmar Stalke

    1. Institute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany)
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  • We would like to thank the State of Lower Saxony, the VW Foundation, the DFG and the Fonds of the Chemical Industry for generous support.

Abstract

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Fast and easy: Various helical tetrasubstituted alkenes were synthesized by a palladium-catalyzed domino process. The domino process consists of a Sonogashira reaction, a carbopalladation, and a direct C[BOND]H functionalization.

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