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Supramolecular Control of Selectivity in Hydroformylation of Vinyl Arenes: Easy Access to Valuable β-Aldehyde Intermediates


  • We kindly acknowledge the NRSC-Catalysis for financial support, Dr. B. de Bruin and Dr. J. I. van der Vlugt for helpful discussions, and Dr. R. Detz for assistance with gas-uptake experiments.


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Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand–substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry.

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