Direct Selective Oxidative Cross-Coupling of Simple Alkanes with Heteroarenes

Authors

  • Dr. Andrey P. Antonchick,

    Corresponding author
    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    • Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)

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  • Lars Burgmann

    1. Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    2. Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44227 Dortmund (Germany)
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  • We gratefully acknowledge Prof. Dr. H. Waldmann for his generous support.

Abstract

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A dream reaction: An efficient and practical method for the oxidative cross-coupling of heteroaromatic compounds and simple alkanes has been developed. The desired products are smoothly and regioselectively formed under mild reaction conditions at ambient temperature in a hypervalent-iodine-mediated transformation. The method allows for preferential transformation of stronger Cmath formula[BOND]H bonds in the presence of weaker Cmath formula[BOND]H bonds under metal-free conditions.

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