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Determination of Labile Chiral Supramolecular Ion Pairs by Chromatographic NMR Spectroscopy


  • We thank ANR (grant number ANR-08-BLAN-273-01) and the Région Provence-Alpes-Côte d’Azur (grant number APO-G-2009), the University of Geneva, and the Swiss National Science Foundation for financial support.


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Chiral recognition: Silica-enhanced NMR diffusometry can distinguish the signals of diastereoisomeric mixtures of supramolecular ion pairs (see picture; DOSY=diffusion-ordered spectroscopy). The experiment has a shorter timescale than liquid chromatography, thus allowing an easier characterization of species that are even configurationally labile on the minutes timescale.

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