We thank Thomas Müller for the mass spectra and Ebba Nexö (Aarhus University) for helpful discussions. R.B. acknowledges support from the National Institutes of Health (DK45776).
Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential “Antivitamin B12”†
Article first published online: 13 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 9, pages 2606–2610, February 25, 2013
How to Cite
Ruetz, M., Gherasim, C., Gruber, K., Fedosov, S., Banerjee, R. and Kräutler, B. (2013), Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential “Antivitamin B12” . Angew. Chem. Int. Ed., 52: 2606–2610. doi: 10.1002/anie.201209651
- Issue published online: 19 FEB 2013
- Article first published online: 13 FEB 2013
- Manuscript Received: 3 DEC 2012
- National Institutes of Health. Grant Number: DK45776
- arene ligands;
- organometallic bonds;
- radical reactions;
Locked B12: 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B12 antimetabolite features a strong CoC bond, and represents a “locked” form of vitamin B12 (see picture). It may be used in animal studies to induce functional vitamin B12 deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B12 deficiency.