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Keywords:

  • arene ligands;
  • cobalamins;
  • organometallic bonds;
  • radical reactions;
  • vitamins
Thumbnail image of graphical abstract

Locked B12: 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B12 antimetabolite features a strong Co[BOND]C bond, and represents a “locked” form of vitamin B12 (see picture). It may be used in animal studies to induce functional vitamin B12 deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B12 deficiency.