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Keywords:

  • gold nanoparticles;
  • nanoparticles;
  • peptide nucleic acids;
  • self-assembly;
  • solid-phase synthesis
Thumbnail image of graphical abstract

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.