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Interaction of Cationic Manganese Porphyrin with G-Quadruplex Nucleic Acids Probed by Differential Labeling of the Two Faces of the Porphyrin


  • This work was supported by ANR grant 07-BLAN-0343.


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On the flip side: A free manganese porphyrin, when activated into a high-valent metal-oxo species, mediates O atom transfer (epoxidation) from both faces. This results in a mixed labeling of epoxide in labeled water. When the porphyrin (blue oval, see scheme) is bound to G-quadruplex DNA (yellow boxes), the O atom transfer reaction takes place only on the accessible face of the porphyrin. This shows the binding mode of the porphyrin to the G-quadruplex DNA.