The Power of Fluorogenic Probes

Authors

  • Dr. André Nadler,

    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • Priv.-Doz. Dr. Carsten Schultz

    Corresponding author
    1. Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
    • Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
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  • The work by the Schultz research group is funded by the EMBL, the ESF (EuroMembraneTraPPs, Schu 943/7-1), the DFG (Transregio 83, SPP1623), the Helmholtz Association (LungSysII), the German Lung Research Center, and the EU (Integrated Project LIVIMODE, ITN Sphingonet).

Abstract

original image

A definite turn-on: Turning on fluorescence only where successful labeling is happening sounds as desirable as delivering a drug only where the drug target resides. New fluorogenic xanthene derivatives from the Bertozzi research group are getting us closer to “magic bullet” dyes (see picture).

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