Catalytic Asymmetric Three-Component Synthesis of Homoallylic Amines


  • We gratefully acknowledge generous financial support from the Max-Planck-Society, the European Research Council (Advanced grant “High Performance Lewis Acid Organocatalysis, HIPOCAT”), and the Alexander von Humboldt Foundation (fellowship for SG).


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It takes three to make things go right: The first direct asymmetric three-component reaction of aldehydes, carbamates, and allyltrimethylsilane leading to enantioenriched homoallylic amines has been developed using a new chiral disulfonimide catalyst (see scheme). The method employs readily available, inexpensive, and nontoxic starting materials and is applicable to both aromatic and aliphatic aldehydes.