Covering all three bases: Drug-delivery vehicles that encapsulate doxorubicin (Dox) within a pH-sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).
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