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Keywords:

  • foldamers;
  • helical structures;
  • peptidomimetics;
  • protein folding;
  • X-ray diffraction
Thumbnail image of graphical abstract

One fold to rule them all: New heterogeneous aliphatic backbone foldamers belonging to the γ-peptide superfamily and containing various combinations of urea/amide (U/A) and urea/carbamate (U/C) units are reported. Structural studies at atomic resolution reveal hydrogen-bonded helical structures akin to that formed by cognate Un homooligomers.