Work in the authors’ laboratory on toxins and pain is supported by grants from the Australian Research Council (DP1093115) and the National Health and Medical Research Council (631457, 1010552, and 1026501.
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Peptides from Mamba Venom as Pain Killers†
Article first published online: 4 FEB 2013
DOI: 10.1002/anie.201209851
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Craik, D. J. and Schroeder, C. I. (2013), Peptides from Mamba Venom as Pain Killers . Angew. Chem. Int. Ed., 52: 3071–3073. doi: 10.1002/anie.201209851
- †
Publication History
- Issue published online: 7 MAR 2013
- Article first published online: 4 FEB 2013
- Manuscript Received: 10 DEC 2012
Funded by
- Australian Research Council. Grant Number: DP1093115
- National Health and Medical Research Council. Grant Numbers: 631457, 1010552, 1026501
- Abstract
- Article
- References
- Cited By
Keywords:
- ion channels;
- pain;
- peptides;
- toxins;
- venoms
The black mamba snake here illustrates the structure of mambaglin-1, a pain-relieving peptide found in its venom. Thick gray lines lines represent the four disulfide bonds linking Cys1–3, 2–4, 5–6, and 7–8. The N-terminus of the 57 amino acid peptide is at the head of the snake and the C-terminus at the tail. The peptide has potential as a pharmacological probe or drug lead. Image design by David Craik and drawing by Peta Harvey, University of Queensland.