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Keywords:

  • domino reactions;
  • lignans;
  • palladium;
  • structure elucidation;
  • total synthesis
Thumbnail image of graphical abstract

Convergent and elegant: Linoxepin (see picture), a new lignan with an unusual oxepin moiety, has been synthesized in only 10 steps. The protecting-group-free total synthesis includes a palladium- catalyzed Sonogashira reaction and a domino carbopalladation/Heck reaction of an allylsilane.