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Keywords:

  • aspidospermidine;
  • asymmetric catalysis;
  • total synthesis;
  • kopsihainanine A;
  • natural products
Thumbnail image of graphical abstract

Functionalized chiral carbazolones with α-quaternary carbon centers are formed through the ligand-controlled Pd-catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)-kopsihainanine A.