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Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer’s Disease

Authors

  • Dr. Vijaya B. Kenche,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Dr. Lin W. Hung,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Keyla Perez,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Irene Volitakes,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Dr. Guiseppe Ciccotosto,

    1. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Department of Pathology, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Jeffrey Kwok,

    1. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Department of Pathology, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Nicole Critch,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Nikki Sherratt,

    1. Department of Pharmacology, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Mikhalina Cortes,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Varsha Lal,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Prof. Colin L. Masters,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Kazuma Murakami,

    1. Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502 (Japan)
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  • Prof. Roberto Cappai,

    1. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Department of Pathology, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Dr. Paul A. Adlard,

    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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  • Prof. Kevin J. Barnham

    Corresponding author
    1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    2. Department of Pharmacology, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    3. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
    • The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010 (Australia)
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Abstract

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Brainwash! A platinum complex (see scheme) was developed that could be administered orally and reduce the amyloid burden in the brains of transgenic mouse models suffering from Alzheimer's disease. Analyses of brain tissues showed that treatment with the Pt compound led to a 26 % decrease in the number of amyloid β-peptide plaques.

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