This study was financed by the Austrian Science Fund within the DK Molecular Enzymology (FWF, project W9), the BMWFJ, BMVIT, SFG, Standortagentur Tirol, and ZIT through the COMET-Program. F.H. and B.v.L. were supported by the BBSRC and F.H. as an ERC Starting Investigator. The authors would like to thank Barbara Grischek, Sebastian Grimm, Gerald Rechberger, and Nina Schmidt for their valuable assistance.
One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases†
Version of Record online: 10 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 11, pages 3277–3279, March 11, 2013
How to Cite
Schober, M., Toesch, M., Knaus, T., Strohmeier, G. A., van Loo, B., Fuchs, M., Hollfelder, F., Macheroux, P. and Faber, K. (2013), One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases. Angew. Chem. Int. Ed., 52: 3277–3279. doi: 10.1002/anie.201209946
- Issue online: 7 MAR 2013
- Version of Record online: 10 FEB 2013
- Manuscript Revised: 12 JAN 2013
- Manuscript Received: 12 DEC 2012
- Funded Access
- Austrian Science Fund
- Standortagentur Tirol
- 3For a conceptually different approach for the cyclic deracemization of amines, see Ref. [2b].
- 10eDepending on CIP priorities, the preference may be formally switched for certain substrates.
- 18The cosolvent has no significant influence on the pH value and does not hamper the workup procedure, but reduces the water activity (aW) of the system, thereby impeding spontaneous (non-enzymatic) hydrolysis.