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Keywords:

  • catalyst recycling;
  • dendrimers;
  • magnetic nanoparticles;
  • palladium;
  • Suzuki coupling
Thumbnail image of graphical abstract

Hold on to your palladium! Phosphines have been grafted on magnetic Co/C nanoparticles through π–π interactions. The resulting Pd complexes showed high activity for Suzuki couplings and the system involving a dendritic ligand was recyclable, allowing the preparation of the drug Felbinac over 12 consecutive runs with minimal Pd leaching. After extraction with CH2Cl2, Felbinac met the requirements of the pharmaceutical industry (<5 ppm Pd).