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Pyrene-Tagged Dendritic Catalysts Noncovalently Grafted onto Magnetic Co/C Nanoparticles: An Efficient and Recyclable System for Drug Synthesis

Authors

  • Dr. Michel Keller,

    1. LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)
    2. Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France)
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  • Vincent Collière,

    1. LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)
    2. Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France)
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  • Prof. Dr. Oliver Reiser,

    1. Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, 93053 Regensburg (Germany)
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  • Dr. Anne-Marie Caminade,

    Corresponding author
    1. LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)
    2. Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France)
    • LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)===

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  • Dr. Jean-Pierre Majoral,

    Corresponding author
    1. LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)
    2. Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France)
    • LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)===

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  • Dr. Armelle Ouali

    Corresponding author
    1. LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)
    2. Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France)
    • LCC-CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France)===

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  • We thank CNRS and ANR Globucat for funding.

Abstract

original image

Hold on to your palladium! Phosphines have been grafted on magnetic Co/C nanoparticles through π–π interactions. The resulting Pd complexes showed high activity for Suzuki couplings and the system involving a dendritic ligand was recyclable, allowing the preparation of the drug Felbinac over 12 consecutive runs with minimal Pd leaching. After extraction with CH2Cl2, Felbinac met the requirements of the pharmaceutical industry (<5 ppm Pd).

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