Copper-Catalyzed Oxidative Cross-Coupling of Sulfoximines and Alkynes


  • This work was supported by the German–Israeli Foundation (G.I.F.). D.L.P. acknowledges support by the Alexander von Humboldt foundation. We also thank Prof. Dr. Jiang Cheng (Changzhou University, China) for helpful discussions.


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A 'Cu'te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.