SEARCH

SEARCH BY CITATION

Keywords:

  • inflammation;
  • nanoparticles;
  • siRNA;
  • supramolecular self-assembly;
  • TNF-α
Thumbnail image of graphical abstract

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50 μg kg−1, and thus protects mice from lipopolysaccharide-induced hepatic injury.