J.C. acknowledges support from the NSF (CHE-1153122) and the NIH (NIH Director’s New Innovator Award 1DP2OD007246 and 1R21EB013379). TNF-α siRNA=tumor necrosis factor-α small interfering RNA.
Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation†
Article first published online: 22 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 22, pages 5757–5761, May 27, 2013
How to Cite
Yin, L., Song, Z., Qu, Q., Kim, K. H., Zheng, N., Yao, C., Chaudhury, I., Tang, H., Gabrielson, N. P., Uckun, F. M. and Cheng, J. (2013), Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation. Angew. Chem. Int. Ed., 52: 5757–5761. doi: 10.1002/anie.201209991
- Issue published online: 17 MAY 2013
- Article first published online: 22 APR 2013
- Manuscript Received: 14 DEC 2012
- NSF. Grant Number: CHE-1153122
- NIH. Grant Numbers: 1DP2OD007246, 1R21EB013379
- supramolecular self-assembly;
A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50 μg kg−1, and thus protects mice from lipopolysaccharide-induced hepatic injury.