Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation


  • J.C. acknowledges support from the NSF (CHE-1153122) and the NIH (NIH Director’s New Innovator Award 1DP2OD007246 and 1R21EB013379). TNF-α siRNA=tumor necrosis factor-α small interfering RNA.


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A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50 μg kg−1, and thus protects mice from lipopolysaccharide-induced hepatic injury.