Palladium-Catalyzed Oxidative Cross-Coupling between Heterocycles and Terminal Alkynes with Low Catalyst Loading

Authors

  • Dr. Xiaoming Jie,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002 (China)
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  • Yaping Shang,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002 (China)
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  • Peng Hu,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002 (China)
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  • Prof. Dr. Weiping Su

    Corresponding author
    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002 (China)
    • State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002 (China)===

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  • Financial support from the 973 Program (2011CB932404, 2001CBA00501), NSFC (20925102) is greatly appreciated.

Abstract

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Direct: With [Pd2(dba)3] as a catalyst, the direct alkynylation of thiophenes bearing a variety of substituents has been accomplished by using terminal alkynes as alkynylating reagents. This protocol is also applicable to other electron-rich aromatic heterocycles. dba=dibenzylidenacetone.

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