This work was supported by the French National Research Agency through the “programme blanc” (grant number ANR-12-BS08-0016-01) and the “programme Labex” (ARCANE project number ANR-11-LABX-003) and funding from the RTB. SEM images were taken at the PFNC platform at MINATEC (CEA Grenoble). P. A. Bayle is acknowledged for solution NMR measurements.
Towards Structure Determination of Self-Assembled Peptides Using Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy†
Article first published online: 5 APR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 27, pages 6979–6982, July 1, 2013
How to Cite
Takahashi, H., Viverge, B., Lee, D., Rannou, P. and De Paëpe, G. (2013), Towards Structure Determination of Self-Assembled Peptides Using Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy. Angew. Chem. Int. Ed., 52: 6979–6982. doi: 10.1002/anie.201210093
- Issue published online: 21 JUN 2013
- Article first published online: 5 APR 2013
- Manuscript Revised: 11 MAR 2013
- Manuscript Received: 18 DEC 2012
- French National Research Agency. Grant Numbers: ANR-12-BS08-0016-01, ANR-11-LABX-003
- dynamic nuclear polarization;
- NMR spectroscopy;
Supra-sensitivity: Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy was performed on self-assembled peptide nanotubes. This approach yields significant experimental time savings (about five orders of magnitude; see picture) and was used to exemplify the feasibility of supramolecular structural studies of organic nanoassemblies at an atomic scale using DNP-enhanced solid-state NMR spectroscopy.