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Keywords:

  • cobalt;
  • diastereoselective protection;
  • natural products;
  • polyketides;
  • total synthesis
Thumbnail image of graphical abstract

Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1,3-cyclohexanedione) derivative by a ring-closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p-toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.