Stereocontrolled Synthesis of Trichodermatide A



This article is corrected by:

  1. Errata: Corrigendum: Stereocontrolled Synthesis of Trichodermatide A Volume 54, Issue 43, 12537, Article first published online: 14 October 2015

  • We gratefully acknowledge the useful suggestions of Prof. Dr. Takayuki Doi (Tohoku University).


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Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1,3-cyclohexanedione) derivative by a ring-closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p-toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.