This work was funded by the Deutsche Forschungsgemeinschaft (DFG). We thank Harry R. Beller and Tim Schöner for providing plasmids and enzymes, Peter Grün for help with compound purification, Imke Schmitt and Francesco Dal Grande for computing time for phylogenetic analysis, and Michael Karas for MALDI access.
Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase†
Article first published online: 19 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 15, pages 4108–4112, April 8, 2013
How to Cite
Fuchs, S. W., Bozhüyük, K. A. J., Kresovic, D., Grundmann, F., Dill, V., Brachmann, A. O., Waterfield, N. R. and Bode, H. B. (2013), Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase . Angew. Chem. Int. Ed., 52: 4108–4112. doi: 10.1002/anie.201210116
- Issue published online: 3 APR 2013
- Article first published online: 19 FEB 2013
- Manuscript Received: 18 DEC 2012
- Deutsche Forschungsgemeinschaft (DFG)
- natural products
Overlooked, but widespread! A new class of ketosynthases (DarB) involved in the biosynthesis of 1,3-cyclohexanediones and dialkylresorcinols has been identified and characterized in detail. The presence of homologues in 89 different bacteria, including several pathogens, reveals that DarB as well as the corresponding natural products might be widespread, thus presenting a new but so far overlooked pathway to natural products.